Canine X-Linked Severe Combined Immune Deficiency
(Redirected from Canine SCID)
Jump to navigation
Jump to search
(Canine SCID)
- Affects Basset Hounds and Corgis
- X-linked recessive defect in the gene coding for the IL-2 receptor
- IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
- Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
- Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases