Canine X-Linked Severe Combined Immune Deficiency

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(Canine SCID)

  • Affects Basset Hounds and Corgis
  • X-linked recessive defect in the gene coding for the IL-2 receptor
    • IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
  • Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
  • Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases