Gastrointestinal Pharmacology quiz

WIKIQUIZ

Questions reviewed by:

Richard Hammond BSc BVetMed DipECVA DVA PhD MRCVS

1

How does the anti-emetic maropitant work? Antagonist at histamine receptor Antagonist at 5-HT3 receptors Antagonist at muscarinic receptor Antagonist at neurokinin (NK1) receptor Agonist at dopamine 2 (D2) receptor Please select an option Incorrect Histamine receptor antagonists e.g. diphenhydramine, are anti-emetics but maropitant works by antagonising the neurokinin (NK1) receptor. It is a relatively new drug which has become licensed in the dog in the UK for treating vomiting and motion sickness. anti-emetics. Incorrect5-HT3 receptor antagonists e.g. ondansetron, are anti-emetics but maropitant works by antagonising the neurokinin (NK1) receptor. It is a relatively new drug which has become licensed in the dog in the UK for treating vomiting and motion sickness. anti-emetics. Incorrect Muscarinic receptor antagonists e.g. hyoscine, are anti-emetics but maropitant works by antagonising the neurokinin (NK1) receptor. It is a relatively new drug which has become licensed in the dog in the UK for treating vomiting and motion sickness. anti-emetics. Correct! Maropitant is a relatively new drug which has become licensed in the dog in the UK for treating vomiting and motion sickness. It works by antagonising the neurokinin (NK1) receptor. anti-emetics. Incorrect Dopamine 2 (D2) receptor agonists e.g. metoclopramide, are anti-emetics but maropitant works by antagonising the neurokinin (NK1) receptor. It is a relatively new drug which has become licensed in the dog in the UK for treating vomiting and motion sickness. anti-emetics.

2

How does the anti-emetic ondansetron work? Agonist at dopamine 2 (D2) receptor Antagonist at muscarinic receptor Antagonist at histamine receptor Antagonist at neurokinin (NK1) receptor Antagonist at 5-HT3 receptors Please select an option Incorrect Dopamine 2 (D2) receptor agonists e.g. metoclopramide, are anti-emetics but ondansetron is a 5-HT3 receptor antagonist. It works by directly inhibiting the chemoreceptor trigger zone and thus inhibiting the vomiting centre. anti-emetics. Incorrect Muscarinic receptor antagonists e.g. hyoscine, are anti-emetics but ondansetron is a 5-HT3 receptor antagonist. It works by directly inhibiting the chemoreceptor trigger zone and thus inhibiting the vomiting centre. anti-emetics. Incorrect Histamine receptor antagonists e.g. diphenhydramine, are anti-emetics but ondansetron is a 5-HT3 receptor antagonist. It works by directly inhibiting the chemoreceptor trigger zone and thus inhibiting the vomiting centre. anti-emetics. Incorrect Neurikinin (NK1) receptor antagonists e.g. maropitant, are anti-emetics but ondansetron is a 5-HT3 receptor antagonist. It works by directly inhibiting the chemoreceptor trigger zone and thus inhibiting the vomiting centre. anti-emetics. Correct! Ondansetron is a 5-HT3 receptor antagonist, which works by directly inhibiting the chemoreceptor trigger zone and thus inhibiting the vomiting centre. anti-emetics.

3

What is the pharmacological mechanism of action of omeprazole? Proton pump inhibitor Histamine (H2) Receptor Antagonist Antacid Binding agent Prostaglandin E Analogue Please select an option Correct! Omeprazole is a proton pump inhibitor which works by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. proton pump inhibitors. Incorrect Histamine receptor antagonists e.g. ranitidine, work by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. Omeprazole is a proton pump inhibitor which works by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. proton pump inhibitors. Incorrect Antacids e.g. magnesium hydroxide,work by chemically neutralising the acidic environment of the stomach. Omeprazole is a proton pump inhibitor which works by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. proton pump inhibitors. Incorrect Binding agents e.g. sucralfate, work by forming a viscous paste in an acidic environment, the binds and protects the mucosal surface. They also stimulate mucus and bicarbonate secretion and the production of prostaglandins. Omeprazole is a proton pump inhibitor which works by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. proton pump inhibitors. Incorrect Prostaglandin E Analogues e.g. misoprostol, work by mimicking the endogenously produced prostaglandins that are gastroprotective. This will therefore inhibit H+ production and increase mucus and bicarbonate production. It will also maintain normal mucosal blood flow. Omeprazole is a proton pump inhibitor which works by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. proton pump inhibitors.

4

What is the pharmacological mechanism of action of ranitidine? Proton pump inhibitor Prostaglandin E Analogue Binding agent Antacid Histamine (H2) receptor antagonist Please select an option Incorrect Proton pump inhibitors e.g. omeprazole, work by binding irreversibly to the H+/K+/ATPase pump and so reducing the secretion of H+ from parietal cells. Omeprazole has a long duration of action as it binds irreversibly to the proton pump. Ranitidine is a histamine receptor antagonist which works by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. histamine receptor antagonist. Incorrect Prostaglandin E Analogues e.g. misoprostol, work by mimicking the endogenously produced prostaglandins that are gastroprotective. This will therefore inhibit H+ production and increase mucus and bicarbonate production. It will also maintain normal mucosal blood flow. Ranitidine is a histamine receptor antagonist which works by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. histamine receptor antagonist. Incorrect Binding agents e.g. sucralfate, work by forming a viscous paste in an acidic environment, the binds and protects the mucosal surface. They also stimulate mucus and bicarbonate secretion and the production of prostaglandins. Ranitidine is a histamine receptor antagonist which works by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. histamine receptor antagonist. Incorrect Antacids e.g. magnesium hydroxide,work by chemically neutralising the acidic environment of the stomach. Ranitidine is a histamine receptor antagonist which works by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. histamine receptor antagonist. Correct! Ranitidine is a histamine receptor antagonist which works by inhibiting the action of histamine on parietal cells. This results in reduced production of H+ ions and pepsin secretion. histamine receptor antagonist.