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  • Hypoparathyroidism may result from primary gland hypofunction.
    • Gland hypofunction occurs due to:
      1. Destruction of secretory cells by a disease process.
        • For example, this may be immune mediated, or another inflammatory cause.
      2. A biochemical defect in synthetic pathway of the hormone.
        • These are usually genetic aberrations.
        • Defects in synthesis are not commonly identified in the veterinary species.