Immunodeficiencies Flashcards

Question	Answer		Article
What is an immunodeficiency?	When the immune system fails to protect itself against disease		Link to Article
True or False: Primary immunodeficiencies only affect the innate immune system	False Primary immunodeficiencies can affect both the innate and adaptive immune systems		Link to Article
What is Canine Cyclic Haematopoeisis?	A primary immunodeficiency Also called Grey Collie Syndrome Due to an autosomal recessive gene insertion Causes cyclic neutropenia every 2 weeks		Link to Article
Name two types of Leukocyte Adhesion Deficiency and what type of mutation is the condition caused by?	Canine (CLAD) Bovine (BLAD) Missence mutation		Link to Article
Is Severe Combined Immune Deficiency disease (SCID) a primary immunodeficiency of the adaptive or the innate immune system?	Adaptive immune system		Link to Article
Which cells are not functioning in animals with SCID?	T cells and B cells		Link to Article
In foals with equine SCID, why does the infection start to develop around 8 weeks of age?	Maternal antibodies from the colostrum start to decrease leaving the animal immunocompromised		Link to Article
What agents can cause a secondary immunodeficiency?	Viruses Toxins Drugs Malnutrition Chronic disease Stress Senescence		Link to Article
What is Feline Leukaemia Virus and what does it cause?	An oncogenic retrovirus Neoplasia Myelosuppression Immunosuppression		Link to Article
How does the FeLV spread in the host?	Replicates in the oropharyngeal lymphoid tissue Causes a viraemia Spreads to the systemic lymphoid system		Link to Article
What treatments are available for FeLV? Antibiotics (to treat the secondary infection) Anti-retroviral therapy			Link to Article
How is Feline Infectious Viraemia (FIV) mainly spread among cats and which cats are most at risk because of this?	Spread mainly by biting Cats living outdoors Feral tom cats		Link to Article

Originally funded by the RVC Jim Bee Award 2007