Liver - Nodular Hyperplasia

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  • common senile change in old dogs


  • multiple spherical nodules in the liver , varying from 0.5 - 3cm in diameter
  • nodules are more friable than normal liver tissue
  • vary in colour from pale to dark (yellow or reddish-tan) or can be the same colour as the rest of the liver
    • the yellowish colour is attributed to fatty change


  • irregular orientation of the hepatic cords
  • cells are larger, may contain more glycogen
  • portal areas still visible within the mass
  • compression of adjacent normal tissue

NB: nodular hyperplasia must NOT be mistaken for neoplasia!