Mycotoxins
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Hepatotoxicity
- metabolites of fungi
- Aflatoxins produced by Aspergillus flavus and other species
- main expression
- chronic intoxication in livestock following fungal growth on badly stored (moisture) grain
- isolated toxins
- B1 - the most potent
- B2
- G1
- G2
- toxic intermediates bind to cellular nuclei acids and proteins
- potent toxins, carcinogens, and teratogens (the last two are less important in domestic animals)
- lesions similar to ragwort poisoning, including the hepatocytic cytomegaly