Mycotoxins

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Hepatotoxicity

  • metabolites of fungi
  • Aflatoxins produced by Aspergillus flavus and other species
  • main expression
    • chronic intoxication in livestock following fungal growth on badly stored (moisture) grain
  • isolated toxins
    • B1 - the most potent
    • B2
    • G1
    • G2
  • toxic intermediates bind to cellular nuclei acids and proteins
    • potent toxins, carcinogens, and teratogens (the last two are less important in domestic animals)
  • lesions similar to ragwort poisoning, including the hepatocytic cytomegaly