Changes

* Most diseases associated with complement are linked to deficiencies of certain components.  

* Most diseases associated with complement are linked to deficiencies of certain components.  

* Some deficiencies give inefficient removal of immune complexes, resulting in autoimmune disease.

* Some deficiencies give inefficient removal of immune complexes, resulting in '''autoimmune disease'''.

 

** E.g. deficiencies in C1, C2, C4 and DAF.

Deficiencies of components like C1, C2, C4, CR1 and DAF lead to autoimmune disease resulting from the inefficient removal immune complexes. This causes these complexes to lodge in many of the small capillary beds and induce inflammation. Most commonly this brings about such diseases as glomerulonephritis, vasculitis, rheumatoid arthritis and inflammation/irritation of the skin, for instance Systemic Lupus Erythematosis.

** Immune complexes lodge ing the small capillary beds and induce inflammation.

 

*** Results in, for example, glomerulonephritis, vasculitis, rheumatoid arthritis and inflammation/ irritation of the skin.

 

** E.g. Systemic Lupus Erythematosis.  

Figure 3

Figure 3