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** C6
 
** C6
 
*** Results in very few effects other that the inability to eliminate encapsulated bacterial infections.  
 
*** Results in very few effects other that the inability to eliminate encapsulated bacterial infections.  
** C1 esterase.
+
** C1 esterase inhibitor.
 
*** A rare genetic deficiency.
 
*** A rare genetic deficiency.
The rare genetic deficiency of C1 esterase inhibitor (an enzyme which controls the functioning of C1 esterase) results in hereditary angiodæma. Lack of this enzyme causes inappropriate activation of C2 and the production of large quantities of C2a (also known as C2 kinin). This is a potent inducer of inflammation and of vasodilatation. The vasodilatation results in the oedema.
+
*** C1 esterase inhibitor is an enzyme which controls the functioning of C1 esterase.
 
+
*** Lack of this enzyme causes inappropriate activation of C2 and production of large quantities of C2a (also known as C2 kinin).  
 +
**** C2 kinin is a potent inducer of inflammation and of vasodilatation.
 +
***** Results in hereditary angiodaema.  
    
<big><center>[[General Pathology|'''BACK TO GENERAL PATHOLOGY''']]</center></big>
 
<big><center>[[General Pathology|'''BACK TO GENERAL PATHOLOGY''']]</center></big>
 
<big><center>[[General Pathology - Immunology|'''BACK TO IMMUNOLOGY''']]</center></big>
 
<big><center>[[General Pathology - Immunology|'''BACK TO IMMUNOLOGY''']]</center></big>
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