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==Introduction==

==Introduction==

 

[[Muscles - Anatomy & Physiology|Muscle]] cells can come from two lineages in the [[Somite Development - Anatomy & Physiology|somite]]. '''Limb and body muscle''' develop from '''hypaxial muscle''' in the lateral regions of the somite. '''Back muscle''' develops from '''epaxial muscle''' in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.

[[Muscles - Anatomy & Physiology|Muscle]] cells can come from two lineages in the [[Somite Development - Anatomy & Physiology|somite]]. '''Limb and body muscle''' develop from '''hypaxial muscle''' in the lateral regions of the somite. '''Back muscle''' develops from '''epaxial muscle''' in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.

==Muscle Cell Differentiation==

==Muscle Cell Differentiation==

'''Prescursor''' mesenchymal cells migrate from the dermomyotome. They divide rapidly en route and are undifferentiated. The cells differentiate to form '''myoblasts''', they are still mesenchymal cells, but can no longer migrate as they are differentiated. They have [[Muscles - Anatomy & Physiology|muscle]] gene expression. The '''myotube''' is formed; cells become multi - nucleated to form a syncytium. Muscle enzymes and the '''myofibre''' is produced. Contractile proteins are present.

'''Precursor''' mesenchymal cells migrate from the dermomyotome. They divide rapidly en route and are undifferentiated. The cells with muscle gene expression differentiate to form '''myoblasts''', they are still mesenchymal cells, but can no longer migrate as they are differentiated. The '''myotube''' is formed and cells become multi - nucleated to form a syncytium. Muscle enzymes and the '''myofibre''' is produced. Contractile proteins are present.

==Limb Muscle Development==

==Limb Muscle Development==

[[Muscles - Anatomy & Physiology#Skeletal Muscle|Skeletal muscle]] of the limbs originates from those [[Somite Development - Anatomy & Physiology|somites]] closest to the limbs. Signalling factors from the limbs cause cells to migrate from the somite and causes the hypaxial lamina to break down, allowing cells to migrate. Few cells migrate; but they rapidly prolifate during migration to increase cell numbers. Muscle precursors migrate into the [[Limb Development - Anatomy & Physiology|limb bud]] (proliferating). At the proximal region of the limb, two populations of cells exists, these are the dorsal and ventral masses. Cells continue migration within these populations. Once cells have reached their destinations, they differentiate.

[[Muscles - Anatomy & Physiology#Skeletal Muscle|Skeletal muscle]] of the limbs originates from those [[Somite Development - Anatomy & Physiology|somites]] closest to the limbs. Signalling factors from the limbs cause cells to migrate from the somite and causes the hypaxial lamina to break down, allowing cells to migrate. Few cells migrate but they rapidly proliferate during migration to increase cell numbers. Muscle precursors migrate into the [[Limb Development - Anatomy & Physiology|limb bud]] (proliferating). At the proximal region of the limb, two populations of cells exists, these are the dorsal and ventral masses. Cells continue migration within these populations. Once cells have reached their destinations, they differentiate.

[[Category:Developmental Biology]][[Category:Musculoskeletal System - Anatomy & Physiology]]

[[Category:Developmental Biology]][[Category:Musculoskeletal System - Anatomy & Physiology]]

[[Category:To Do - AimeeHicks]][[Category:To Do - Review]]

[[Category:A&P Done]]