[[Muscles - Anatomy & Physiology#Skeletal Muscle|Skeletal muscle]] of the limbs originates from those [[Somite Development - Anatomy & Physiology|somites]] closest to the limbs. Signalling factors from the limbs cause cells to migrate from the somite and causes the hypaxial lamina to break down, allowing cells to migrate. Few cells migrate but they rapidly proliferate during migration to increase cell numbers. Muscle precursors migrate into the [[Limb Development - Anatomy & Physiology|limb bud]] (proliferating). At the proximal region of the limb, two populations of cells exists, these are the dorsal and ventral masses. Cells continue migration within these populations. Once cells have reached their destinations, they differentiate. | [[Muscles - Anatomy & Physiology#Skeletal Muscle|Skeletal muscle]] of the limbs originates from those [[Somite Development - Anatomy & Physiology|somites]] closest to the limbs. Signalling factors from the limbs cause cells to migrate from the somite and causes the hypaxial lamina to break down, allowing cells to migrate. Few cells migrate but they rapidly proliferate during migration to increase cell numbers. Muscle precursors migrate into the [[Limb Development - Anatomy & Physiology|limb bud]] (proliferating). At the proximal region of the limb, two populations of cells exists, these are the dorsal and ventral masses. Cells continue migration within these populations. Once cells have reached their destinations, they differentiate. |