Changes

==What can this indicate==

==What can this indicate==

A stress leucogram can be completely normal as part of the stress response.  It is caused by endogenous release of adrenaline/epinephrine which causes the above haematological parameters to change, this release can be triggered by pain, stress or excitement.  See below for the mechanism for this change.   

A stress leucogram can be completely normal as part of the stress response.  It is caused by endogenous release of adrenaline/epinephrine which causes the release of cortisol from the adrenal cortex - this causes the haematological parameters to change.  Adrenaline and then cortisol release can be triggered by pain, stress or excitement.   

A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of adrenaline released endogenously, or via iatrogenic injection of exogenous corticosteroids.

A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of cortisol released endogenously, or via iatrogenic injection of exogenous corticosteroids.

==How does it occur?==

==How does it occur?==

The corticosteroid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination

The corticosteroid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination