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Ferrets (Laboratory) - Pathology (view source)
Revision as of 16:49, 4 March 2011
, 16:49, 4 March 2011→Respiratory System
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Gross lesions will include consolidation of the cranioventral lung lobes, either uni or bi-laterally. The severity of the lesions will be proportionate to the length of time since the aspiration occurred. In most cases minimal lesions will be visible but in severe and long-standing cases gangerenous, cavitated lesions may be seen within the pulmonary parenchyma. Microscopic findings may include primary lesions within the small airways. Bronchioles may contain a variable mixture of viable and degenerate neutrophils, sloughed epithelial cells and enosinophilic proteinaceous material (particularly if the aspirate is vomit based). There may also be a foamy accumulation of macrophages in surrounding alveoli. In long-standing cases there may be a pronounced granulomatous response with numerous foreign bodies. Where vomit has been aspirated there may also be extensive necrosis of the airways and surrounding alveoli with sloughing of the bronchiolar epithelium.#
Gross lesions will include consolidation of the cranioventral lung lobes, either uni or bi-laterally. The severity of the lesions will be proportionate to the length of time since the aspiration occurred. In most cases minimal lesions will be visible but in severe and long-standing cases gangerenous, cavitated lesions may be seen within the pulmonary parenchyma. Microscopic findings may include primary lesions within the small airways. Bronchioles may contain a variable mixture of viable and degenerate neutrophils, sloughed epithelial cells and enosinophilic proteinaceous material (particularly if the aspirate is vomit based). There may also be a foamy accumulation of macrophages in surrounding alveoli. In long-standing cases there may be a pronounced granulomatous response with numerous foreign bodies. Where vomit has been aspirated there may also be extensive necrosis of the airways and surrounding alveoli with sloughing of the bronchiolar epithelium.
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'''Influenza'''
'''Influenza'''
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Ferrets are the only domestic species that are susceptible to human influenza viruses which, as mentioned in the introduction, is why they are a key laboratory animal. As a result, infection from human to animal is possible. Clinical signs are similar to those in humans including photophobia, a catarrhal nasal discharge, sneezing, coughing, pyrexia, anorexia and malaise. The disease is rarely fatal.
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Gross lesions are minimal but may include congestion and exudation of the nasal mucosa and mild reddening of the tracheal mucosa. Microscopic lesions may include a mild sub-acute inflammation and occasional necrosis of the nasal mucosa. A mild sub-acute interstitial pneumonia may also be present.
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