Chordomas are the most common form of musculoskeletal neoplasm in ferrets and arise either in or adjacent to vertebra from remnants of the primitive notochord. These most commonly occur in the tip of the tail but have been reported in the cervical area. Chordomas are considered potentially malignant although metastasis has not been reported in neoplasms arising in the tail.
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===Metastatic Calcification===
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Gross lesions from chordomas are usually seen as club-like swellings at the tip of the tail, involving the last caudal vertebrae. Cervical chordomas often present as lytic neoplasms together with posterior paralysis. Microscopic lesions will manifest as locally aggressive neoplasms often infiltrating the vertebral bodies. The neoplasm itself will usually be composed of foamy "physaliferous cells" (having vaculoes) which are seperated by a moderate amount of myxomatous matrix (weakening of connective tissue). There may also be multifocal areas of well-differentiated cartilage and bone within the neoplasms.