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Ferrets (Laboratory) - Pathology (view source)
Revision as of 17:53, 4 March 2011
, 17:53, 4 March 2011→Integument System
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Gross lesions for sebaceous epitheliomas will appear as warty, verrucous lesions that can arise anywhere on the animal's body, but are most often seen on the head and neck. Microscopic lesions for sebaceous epitheliomas will include an unencapsulated neoplasm composed of basal cells of which a small percentage will exhibit sebaceous and or squamous differentiation. These cells are reported to have no features of malignancy or metastatic abilities. Gross lesions for mast cell tumors will appear as flat, alopecic, hyperkeratotic plaques which are variably pruritic. Microscopic lesions will include a well demarcated, unencapsulated neoplasm that is commonly confined to the superficial dermis and will be composed of well differentiated mast cells. Small numbers of eosinophils will be scattered throughout the neoplasm. Vasculitis and/or collagen are rarely seen. Gross lesions for leiomyomas are often well encapsulated but have no metastatic potential.
Gross lesions for sebaceous epitheliomas will appear as warty, verrucous lesions that can arise anywhere on the animal's body, but are most often seen on the head and neck. Microscopic lesions for sebaceous epitheliomas will include an unencapsulated neoplasm composed of basal cells of which a small percentage will exhibit sebaceous and or squamous differentiation. These cells are reported to have no features of malignancy or metastatic abilities. Gross lesions for mast cell tumors will appear as flat, alopecic, hyperkeratotic plaques which are variably pruritic. Microscopic lesions will include a well demarcated, unencapsulated neoplasm that is commonly confined to the superficial dermis and will be composed of well differentiated mast cells. Small numbers of eosinophils will be scattered throughout the neoplasm. Vasculitis and/or collagen are rarely seen. Gross lesions for leiomyomas are often well encapsulated but have no metastatic potential.
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'''Dermatomycosis'''
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This disease is uncommon in ferrets but may occur in either young, old or immunosuppressed animals kept in poor conditions. ''Microsporum canis'' and ''Trichophyton mentagrophytes'' have been reported as causative agents.
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Gross lesions include areas of crusting alopecia with brittle hair and broken hair shafts. In immunosuppressed animals, any associated rashes can become generalised. Microscopic lesions from biopsies taken from affected sites will include a thick layer of keratin debris, degenerate neutrophils and fungal arthrospores with hyphae. There will be ulceration of the skin and hair follicles will often contain numerous fungal arthrospores which can occasionally invade the hair shaft. Many follicles will not contain a hair shaft at all and will contain only lamellar keratin debris. There may also be a generalised neutrophilic or lymphoplasmacytic dermal infiltrate in perivascular and periadnexal areas.
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