'''Volume overload '''e.g. Valve regurgitation and shunts ([[Patent Ductus Arteriosus|PDA]]). Initial response based on the '''Frank-Starling Law''' and stroke volume increases as preload increases and enables the heart to expel the extra blood. Ultimately the heart decompensates and the chamber enlarges. Fluid will build up in the compartment preceding it. For example, failure of the left atrium in this manner due to mitral regurgitation leads to [[Pulmonary Oedema|pulmonary oedema]]. | '''Volume overload '''e.g. Valve regurgitation and shunts ([[Patent Ductus Arteriosus|PDA]]). Initial response based on the '''Frank-Starling Law''' and stroke volume increases as preload increases and enables the heart to expel the extra blood. Ultimately the heart decompensates and the chamber enlarges. Fluid will build up in the compartment preceding it. For example, failure of the left atrium in this manner due to mitral regurgitation leads to [[Pulmonary Oedema|pulmonary oedema]]. |