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Equine Internal Medicine Q&A 16 (view source)
Revision as of 07:59, 1 June 2011
, 07:59, 1 June 2011Created page with "{{Template:Manson Mair}} centre|500px<br> <br /> '''A nine-week-old Arabian foal is presented with a history of recurrent respira..."
{{Template:Manson Mair}}
[[Image:Equine Internal Medicine Q&A 15.jpg|centre|500px]]<br>
<br />
'''A nine-week-old Arabian foal is presented with a history of recurrent respiratory infections characterized by nasal discharge, cough, dyspnoea and pyrexia. The foal was normal at birth, but suffered its first bout of respiratory disease at six weeks of age. Over the previous week it had also developed widespread scaling and alopecic skin lesions, from which Dermatophilus congolensis had been cultured. The foal has also had intermittent diarrhoea. Haematological evaluation revealed a severe lymphopenia (lymphocyte count 0.2x109/l).'''
<br />
<FlashCard questions="5">
|q1=What is the most likely diagnosis?
|a1=Combined immunodeficiency syndrome (CID).
|l1=
|q2=How could you confirm this?
|a2=
*Serum IgM will be extremely low or undetectable.
*The lymphopenia will be persistent.
*Lymphoid hypoplasia, including the thymus, spleen and lymph nodes, will be evident at post-mortem examination.
|l2=
|q3=What is the aetiology of this disease?
|a3=
*CID is a genetic disorder of foals of Arabian breeding that results in failure to produce functional B and T lymphocytes. <br><br>
*The disease is inherited as an autosomal recessive trait, and heterozygous individuals show no signs. <br><br>
*Affected foals are usually normal at birth, and signs of infection (especially respiratory infections and pneumonia) become evident at any time between two days and two months depending on the level of passively acquired colostral immunity.
|l3=
|q4=What are the usual causes of the respiratory infections in this disease?
|a4=Pneumonia caused by adenovirus, ''Pneumocystis carinii'' and a variety of bacteria are commonly involved.
|l4=
|q5=How would you treat this foal?
|a5=There is no recommended treatment for CID. Bone marrow transplantation has been performed successfully in one affected foal.
|l5=
</FlashCard>
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[[Category:Equine Internal Medicine Q&A]]
[[Image:Equine Internal Medicine Q&A 15.jpg|centre|500px]]<br>
<br />
'''A nine-week-old Arabian foal is presented with a history of recurrent respiratory infections characterized by nasal discharge, cough, dyspnoea and pyrexia. The foal was normal at birth, but suffered its first bout of respiratory disease at six weeks of age. Over the previous week it had also developed widespread scaling and alopecic skin lesions, from which Dermatophilus congolensis had been cultured. The foal has also had intermittent diarrhoea. Haematological evaluation revealed a severe lymphopenia (lymphocyte count 0.2x109/l).'''
<br />
<FlashCard questions="5">
|q1=What is the most likely diagnosis?
|a1=Combined immunodeficiency syndrome (CID).
|l1=
|q2=How could you confirm this?
|a2=
*Serum IgM will be extremely low or undetectable.
*The lymphopenia will be persistent.
*Lymphoid hypoplasia, including the thymus, spleen and lymph nodes, will be evident at post-mortem examination.
|l2=
|q3=What is the aetiology of this disease?
|a3=
*CID is a genetic disorder of foals of Arabian breeding that results in failure to produce functional B and T lymphocytes. <br><br>
*The disease is inherited as an autosomal recessive trait, and heterozygous individuals show no signs. <br><br>
*Affected foals are usually normal at birth, and signs of infection (especially respiratory infections and pneumonia) become evident at any time between two days and two months depending on the level of passively acquired colostral immunity.
|l3=
|q4=What are the usual causes of the respiratory infections in this disease?
|a4=Pneumonia caused by adenovirus, ''Pneumocystis carinii'' and a variety of bacteria are commonly involved.
|l4=
|q5=How would you treat this foal?
|a5=There is no recommended treatment for CID. Bone marrow transplantation has been performed successfully in one affected foal.
|l5=
</FlashCard>
{{#tag:imagemap|Image:Next Question.png{{!}}center{{!}}200px
rect 0 0 860 850 [[Equine Internal Medicine Q&A 17|Next question]]
desc none}}
[[Category:Equine Internal Medicine Q&A]]