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[[File:BSE 2.jpg|thumb|200px|left|A cow suffering from BSE - recumbent, low body condition score and difficulty rising.]]
 
[[File:BSE 2.jpg|thumb|200px|left|A cow suffering from BSE - recumbent, low body condition score and difficulty rising.]]
 
The first sign is usually separation from the herd and reluctance to move into the milking parlour and the cows may respond by with vigorous kicking. BSE-affected cattle show ‘’progressive neurological and behavioural changes’’, abnormalities of posture and movement, recumbency, changes in sensation and ‘’temperament’’ and increased aggression.  Nervousness, tremors, falling, hyperaesthesia to sound and touch and ‘’progressive weakness and hind-limb ataxia’’ and agalactia or ‘’decreased milk yield’’ are the most prominent clinical signs. Other clinical signs include anorexia, weight loss, bruxism, ptyalism, trismus, pruritus and dull rough coat and ophthalmic signs including blindness, lacrimation, ptosis and prolapsed third eyelid.  
 
The first sign is usually separation from the herd and reluctance to move into the milking parlour and the cows may respond by with vigorous kicking. BSE-affected cattle show ‘’progressive neurological and behavioural changes’’, abnormalities of posture and movement, recumbency, changes in sensation and ‘’temperament’’ and increased aggression.  Nervousness, tremors, falling, hyperaesthesia to sound and touch and ‘’progressive weakness and hind-limb ataxia’’ and agalactia or ‘’decreased milk yield’’ are the most prominent clinical signs. Other clinical signs include anorexia, weight loss, bruxism, ptyalism, trismus, pruritus and dull rough coat and ophthalmic signs including blindness, lacrimation, ptosis and prolapsed third eyelid.  
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