Changes

==Diagnosis==

==Diagnosis==

'''Virus isolation and histopathology'' should be performed on the main site of replication which will vary with disease and virus species as discussed in clinical signs. '''Intranuclear inclusion bodies''' are common and suggestive but not specific to adenoviruses. The virus can be innoculated into cell cultures and easily identified by '''electron microscopy or staining with fluorescent antisera'''. Serum neutralisation can be used to determine individual species using standard antisera.

'''Virus isolation and histopathology''' should be performed on the main site of replication which will vary with disease and virus species as discussed in clinical signs. '''Intranuclear inclusion bodies''' are common and suggestive but not specific to adenoviruses. The virus can be innoculated into cell cultures and easily identified by '''electron microscopy or staining with fluorescent antisera'''. Serum neutralisation can be used to determine individual species using standard antisera.

Antigen can be detected using '''double immunodiffusion''' which is specific to serogroup.

Antigen can be detected using '''double immunodiffusion''' which is specific to serogroup.