Microglia are the CNS version of a mononuclear phagocyte system as the normal phagocytic white blood cells are unable to cross the blood-brain barrier. Microglial cells are derived from [[Bone Marrow - Anatomy & Physiology|bone marrow]] and are first seen in the brain just prior to the vascularistion stage of brain development. There are two populations of microglial cells; extrinsic cells which are located perivascularly and in the meninges, and intrinsic cells which are located within the substance of the neural tissue. | Microglia are the CNS version of a mononuclear phagocyte system as the normal phagocytic white blood cells are unable to cross the blood-brain barrier. Microglial cells are derived from [[Bone Marrow - Anatomy & Physiology|bone marrow]] and are first seen in the brain just prior to the vascularistion stage of brain development. There are two populations of microglial cells; extrinsic cells which are located perivascularly and in the meninges, and intrinsic cells which are located within the substance of the neural tissue. |