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mLine 29:
Line 29: − * PROTEIN METABOLISM+ − * CARBOHYDRATE METABOLISM+ + − * LIPID METABOLISM+ + − * BIOTRANSFORMATION AND EXCRETION+ + − * IMMUNOLOGICAL FUNCTIONS+ + − * VITAMIN ACTIVATION, STORAGE AND ELIMINATION+ − * STORAGE OF MINERALS (IRON, COPPER, ZINC, MANGANESE)+ − * INACTIVATION OF ENDOCRINE HORMONE+ + + + + Line 67:
Line 75: + + + + + + + + + + + + + + + + − [[Category:Liver - General Pathology]]+ − [[Category:To_Do_-_Clinical]] − [[Category:To Do - Siobhan Brade]]
no edit summary
==Liver Function==
==Liver Function==
===Protein Synthesis===
Protein synthesis, regulation of amino acids Ammonia synthesis and detoxification
Protein synthesis, regulation of amino acids Ammonia synthesis and detoxification
===Carbohydrate Metabolism===
Blood glucose regulation Maintenance of glycogen reserve Regulation of intermediary carbohydrate metabolism
Blood glucose regulation Maintenance of glycogen reserve Regulation of intermediary carbohydrate metabolism
===Lipid Metabolism===
Synthesis of cholesterol, phospholipids and lipoproteins; fatty acid oxidation Bile acid synthesis and regulation
Synthesis of cholesterol, phospholipids and lipoproteins; fatty acid oxidation Bile acid synthesis and regulation
===Biotransformation and Excretion===
Bilirubin, ammonia, steroid hormones Drugs, copper, cholesterol
Bilirubin, ammonia, steroid hormones Drugs, copper, cholesterol
===Immunological Functions===
Antigen trapping by Kupffer's cells Synthesis of complement, interleukin
Antigen trapping by Kupffer's cells Synthesis of complement, interleukin
===Vitamin Storage, Activation and Elimination===
===Storage of Minerals===
IRON, COPPER, ZINC, MANGANESe
===Inactivation of Endocrine Hormones===
==Clinical Signs==
==Clinical Signs==
* Coagulation profile
* Coagulation profile
plasma ammonia
abdominocentesis
===Biopsy===
==Treatment==
* Remove causative agent
* Stop inflammation
* Minimise fibrosis
* Promote regeneration
* Treat secondary complications such a ascites, secondary bacterial infection and hepatic encephalopathy.
==References==
Rutgers, C (1996) '''Liver disease in dogs''' ''In Practice 1996 18: 433-44''
Rutgers, C (1996) ''Feline liver disease''' ''In Practice 1998 20: 16-2''
Dunn, j (1992) '''Assessment of liver damage and function''' ''In Practice 1992 14: 193-200''
Bexfield, N & Watson, P (2006) '''Diagnosis of canine liver disease''' ''In Practice 2006 28: 444-45''