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mLine 27:
Line 27: − + − [[Icterus]]+ + + + + + + + + + + + + − [[Photosensitisation]]+ + − + + + + + + + + + + + + + + + + + + + + − [[Bleeding Tendencies]] − [[Hypoalbuminaemia]]
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*Lowered level of plasma albumin contributes to the development of ascites
*Lowered level of plasma albumin contributes to the development of ascites
==Syndromes in liver failure==
==Liver Function==
* PROTEIN METABOLISM
Protein synthesis, regulation of amino acids Ammonia synthesis and detoxification
* CARBOHYDRATE METABOLISM
Blood glucose regulation Maintenance of glycogen reserve Regulation of intermediary carbohydrate metabolism
* LIPID METABOLISM
Synthesis of cholesterol, phospholipids and lipoproteins; fatty acid oxidation Bile acid synthesis and regulation
* BIOTRANSFORMATION AND EXCRETION
Bilirubin, ammonia, steroid hormones Drugs, copper, cholesterol
* IMMUNOLOGICAL FUNCTIONS
Antigen trapping by Kupffer's cells Synthesis of complement, interleukin
* VITAMIN ACTIVATION, STORAGE AND ELIMINATION
* STORAGE OF MINERALS (IRON, COPPER, ZINC, MANGANESE)
* INACTIVATION OF ENDOCRINE HORMONE
==Clinical Signs==
The animal may present with non specific signs such as weight loss, anorexia, vomiting, diarrhoea, lethargy and PU/PD. The may also present with syndromes specifically related to primary or secondary liver disease such as:
[[Hepatic Encephalopathy]]
* [[Icterus]]
* [[Photosensitisation]]
* [[Hepatic Encephalopathy]]
* [[Bleeding Tendencies]] or coagulopathy
* [[Hypoalbuminaemia]] and ascites
* Hepatomegaly or fibrosis of the liver
* Drug intolerance
==Diagnosis==
===Laboratory Tests===
* Haematology, biochemistry, urinanalysis
* Serum bile acid test pre- and post-prandial
* Coagulation profile