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[[Icterus]]+[[Photosensitisation]]+
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+[[Bleeding Tendencies]]
−[[Hypoalbuminaemia]]
*Lowered level of plasma albumin contributes to the development of ascites
*Lowered level of plasma albumin contributes to the development of ascites
−==Syndromes in liver failure==
+==Liver Function==
−* PROTEIN METABOLISM
+Protein synthesis, regulation of amino acids Ammonia synthesis and detoxification
+* CARBOHYDRATE METABOLISM
+Blood glucose regulation Maintenance of glycogen reserve Regulation of intermediary carbohydrate metabolism
+* LIPID METABOLISM
+Synthesis of cholesterol, phospholipids and lipoproteins; fatty acid oxidation Bile acid synthesis and regulation
+* BIOTRANSFORMATION AND EXCRETION
+Bilirubin, ammonia, steroid hormones Drugs, copper, cholesterol
+* IMMUNOLOGICAL FUNCTIONS
+Antigen trapping by Kupffer's cells Synthesis of complement, interleukin
+* VITAMIN ACTIVATION, STORAGE AND ELIMINATION
+* STORAGE OF MINERALS (IRON, COPPER, ZINC, MANGANESE)
+* INACTIVATION OF ENDOCRINE HORMONE
−==Clinical Signs==
+The animal may present with non specific signs such as weight loss, anorexia, vomiting, diarrhoea, lethargy and PU/PD. The may also present with syndromes specifically related to primary or secondary liver disease such as:
−[[Hepatic Encephalopathy]]
+* [[Icterus]]
+* [[Photosensitisation]]
+* [[Hepatic Encephalopathy]]
+* [[Bleeding Tendencies]] or coagulopathy
+* [[Hypoalbuminaemia]] and ascites
+* Hepatomegaly or fibrosis of the liver
+* Drug intolerance
+==Diagnosis==
+===Laboratory Tests===
+* Haematology, biochemistry, urinanalysis
+* Serum bile acid test pre- and post-prandial
+* Coagulation profile
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