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→Canine Distemper Virus (CDV)
**Keratitis
**Keratitis
**[[Lungs - inflammatory#Interstitial pneumonia|Interstitial pneumonia]]
**[[Lungs - inflammatory#Interstitial pneumonia|Interstitial pneumonia]]
**Severe clinical pneumonia follows secondary infection with ''Bordetella bronchiseptica''
**Smelly sometimes bloody diarrhoea
**Smelly sometimes bloody diarrhoea
**Eruptions on the skin including hyperkeratosis of the nose and pads (hardpad)
**Eruptions on the skin including hyperkeratosis of the nose and pads (hardpad)
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
**Recovered animals may have persistent or spasmodic chorea
**Recovered animals may have persistent or spasmodic chorea
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes.
*'''Diagnosis''':
**May present as series of infections
**'''Immunocytochemistry''' of inclusion bodies
Intracytoplasmic inclusions may be found in most affected tissues
***Intracytoplasmic inclusions may be found in most affected tissues
***Inclusions persist longest in the brain (may be intranuclear) and the alveolar macrophages
***Sections of fixed bronchial tissue, lung, macrophages, bladder may be used or nasal or conjunctival epithelium from live animals
**Giant cells may be seen in the alveoli
*'''Control''':
**Live attenuated virus vaccines given at 10 and 12 weeks of age
***Some now given at 7 and 10 weeks to allow socialisation
**Homeopathic vaccines do not work
**Live attenuated vaccines may kill some wildlife therefore '''Iscom vaccine''' is used in seal sanctuaries
*Can contribute to [[Viral infections#In Dogs|Infectious canine tracheitis]]
*Can contribute to [[Viral infections#In Dogs|Infectious canine tracheitis]]