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== Introduction ==

== Introduction ==

Hepatic lipidosis describes a syndrome caused by derangements in lipid and protein metabolism. It occurs in both cats and dogs but produces a more important clinical syndrome in cats. Similar phenomena occur in [[Hyperlipaemia - Horse|horses]], [[Hyperlipaemia - Donkey|donkeys]], [[Fatty Liver Syndrome|cattle]] and [[Pregnancy Toxaemia|sheep]] when they are exposed to periods of metabolic stress. Hepatic lipidosis may be '''primary''' (or idiopathic) or it may be '''secondary''' to another disease.  

Hepatic lipidosis describes a syndrome caused by derangements in lipid and protein metabolism. It occurs in cats, dogs and chelonia but produces a more important clinical syndrome in cats. Similar phenomena occur in [[Hyperlipaemia - Horse|horses]], [[Hyperlipaemia - Donkey|donkeys]], [[Fatty Liver Syndrome|cattle]] and [[Pregnancy Toxaemia|sheep]] when they are exposed to periods of metabolic stress. Hepatic lipidosis may be '''primary''' (or idiopathic) or it may be '''secondary''' to another disease.  

=== Primary Lipidosis ===

=== Primary Lipidosis ===

=== Secondary Lipidosis ===

=== Secondary Lipidosis ===

'''Secondary hepatic lipidosis''' is a neuroendocrine response to other diseases, including [[Pancreatitis|pancreatitis]], [[Diabetes Mellitus|diabetes mellitus]], [[Inflammatory Bowel Disease|inflammatory bowel disease]] and primary hypertriglyceridaemia. Secondary hepatic lipidosis is therefore less closely associated with obesity and it may be seen in normal or even thin cats. In dogs, this secondary lipid accumulation rarely contributes to the clinical syndrome but in cats, it may greatly exacerbate the disease suffered by the affected animal. ''Secondary lipidosis is much more common than primary in cats in the UK. ''

'''Secondary hepatic lipidosis''' is a neuroendocrine response to other diseases, including [[Pancreatitis|pancreatitis]], [[Diabetes Mellitus|diabetes mellitus]], [[Inflammatory Bowel Disease|inflammatory bowel disease]] and primary hypertriglyceridaemia. Secondary hepatic lipidosis is therefore less closely associated with obesity and it may be seen in normal or even thin cats. In dogs, this secondary lipid accumulation rarely contributes to the clinical syndrome but in cats, it may greatly exacerbate the disease suffered by the affected animal. ''Secondary lipidosis is much more common than primary in cats in the UK. ''  

== Signalment ==

== Signalment ==

Indoor and obese cats are more prone to the development of primary hepatic lipidosis during periods of stress or anorexia. Most cases occur in middle-aged cats with no apparent breed predisposition.  

Indoor and obese cats are more prone to the development of primary hepatic lipidosis during periods of stress or anorexia. Most cases occur in middle-aged cats with no apparent breed predisposition. The development of hepatic lipidosis in chelonia is most commonly a consequence of feeding a high fat diet such as commercial pet food, so there are no age, breed or sex predispositions. 

== Clinical Signs ==

== Clinical Signs ==

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[[Category:Liver_-_Degenerative_Pathology]] [[Category:Liver_Diseases_-_Cat]] [[Category:Expert_Review]] [[Category:Liver_Diseases_-_Dog]]

[[Category:Liver_-_Degenerative_Pathology]] [[Category:Liver_Diseases_-_Cat]] [[Category:Expert_Review]] [[Category:Liver_Diseases_-_Dog]]