Changes

===Loop Diuretics===  

===Loop Diuretics===  

Loop diuretics work on the [[Reabsorption and Secretion Along the Loop of Henle - Anatomy & Physiology#Thick ascending limb|thick ascending limb]] of the loop of Henle by inhibiting the activity of the sodium/potassium/2-chloride symporter.  Approximately 20-25% of sodium is reabsorbed via this symporter, so inhibition of it causes an increase in distal tubular sodium deliver, increased water loss, and increased sodium loss. As a result the hypertonicity of the medulla decreases and therefore water uptake from the loop of Henle also decreases.  Increased amounts of all three ions are lost as a result.   

Loop diuretics work on the [[Reabsorption and Secretion Along the Loop of Henle - Anatomy & Physiology#Thick ascending limb|thick ascending limb]] of the loop of Henle by inhibiting the activity of the sodium/potassium/2-chloride symporter.  Approximately 20-25% of sodium is reabsorbed via this symporter, so inhibition of it causes an increase in distal tubular sodium delivery, increased water loss, and increased sodium loss. As a result the hypertonicity of the medulla decreases and therefore water uptake from the loop of Henle also decreases.  Increased amounts of all three ions are lost as a result.   

As well as reducing the re-uptake of water they also increase renal blood flow via [[Glomerular Filtration Rate#Nitrous Oxide and Prostaglandins|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.

As well as reducing the re-uptake of water they also increase renal blood flow via [[Glomerular Filtration Rate#Nitrous Oxide and Prostaglandins|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.