Changes

==Introduction==

 

=Immune Tolerance=

Immunological tolerance occurs when there is unresponsiveness towards particular antigens, so any further immune responses are prevented or suppressed. Tolerance is required to prevent:

Immunological tolerance occurs when there is unresponsiveness towards particular antigens, so any further immune responses are prevented or suppressed. Tolerance is required to prevent:

* Potentially harmful inflammatory responses towards innocuous substances, such as air-borne or food molecules

* Potentially harmful inflammatory responses towards innocuous substances, such as air-borne or food molecules

Regulatory T cells are unique in their use of a transcription repressor known as FoxP3 which is encoded by a gene on the X chromosome; rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.

Regulatory T cells are unique in their use of a transcription repressor known as FoxP3 which is encoded by a gene on the X chromosome; rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.

==Test yourself with the Immunology Flashcards==

[[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]

|flashcards = [[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]

 

|literature search =[http://www.cabdirect.org/search.html?q=title:(%22immune+tolerance%22)+OR+title:(%22t+cell+tolerance%22)+OR+title:(%22mucosal+tolerance%22)&fq=sc:%22ve%22 Immune Tolerance publications]

==Literature Search==

 

 

[http://www.cabdirect.org/search.html?q=title:(%22immune+tolerance%22)+OR+title:(%22t+cell+tolerance%22)+OR+title:(%22mucosal+tolerance%22)&fq=sc:%22ve%22 Immune Tolerance publications]

[http://www.cabdirect.org/search.html?q=title:(%22regulatory+t+cells%22)&fq=sc:%22ve%22 Regulatory T-cell publications]

[http://www.cabdirect.org/search.html?q=title:(%22regulatory+t+cells%22)&fq=sc:%22ve%22 Regulatory T-cell publications]

 

[[Category:Immunology]]

[[Category:Immunology]]