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Immune Tolerance Flashcards (view source)

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==Immune tolerance==

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~~{| border~~="~~3" cellpadding="8~~"

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~~!width="400"~~|~~'''Question'''~~

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|q1=What is the definition of tolerance?

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~~!width~~=~~"400"|'''Answer'''~~

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|a1=A state of immune unresponsiveness towards antigens

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~~!width="150"|'''Article'''~~

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|l1=Immune Tolerance

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|q2=Where does central tolerance develop?

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~~|<big>'''~~What is the definition of tolerance?~~'''~~

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|a2=Thymus

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|~~| <big>~~

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|l2=Immune Tolerance

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*'''''A state of immune unresponsiveness towards antigens~~'''''~~

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|q3=What are the two processes of selection known as?

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|a3=

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|-

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*Positive selection

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~~|<big>'''~~Where does central tolerance develop?~~'''~~

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*Negative selection

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|~~| <big>~~

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|l3=Immune Tolerance

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*'''''Thymus~~'''''~~

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|q4=What are the four ways peripheral tolerance can be achieved in T cells?

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|a4=

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|-

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*Ignorance

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~~|<big>'''~~What are the two processes of selection known as?~~'''~~

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*Anergy

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|~~| <big>~~

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*Cell death

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*~~'''''~~Positive selection~~'''''~~

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*Immune deviation/suppression

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*~~'''''~~Negative selection~~'''''~~

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|l4=Immune Tolerance

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|q5=What is the process in which one T cell response is selectively induced over another?

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|-

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|a5=Immune deviation

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~~|<big>'''~~What are the four ways peripheral tolerance can be achieved in T cells?~~'''~~

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|l5=Immune Tolerance

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|~~| <big>~~

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|q6='''What subtype are regulatory T cells?

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*~~'''''~~Ignorance~~'''''~~

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|a6=CD4+

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*~~'''''~~Anergy~~'''''~~

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|l6=Immune Tolerance

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*~~'''''~~Cell death~~'''''~~

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|q7=What part of the body do Treg cells develop?

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*~~'''''~~Immune deviation/suppression~~'''''~~

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|a7=Thymus

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|l7=Immune Tolerance

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|-

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|q8=What typical inhibitory cytokines do Treg cells secrete?

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~~|<big>'''~~What is the process in which one T cell response is selectively induced over another?~~'''~~

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|a8=

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|~~| <big>~~

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*IL-4

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*'''''Immune deviation~~'''''~~

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*IL-10

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|~~|[[~~Immune Tolerance~~|Link to Answer Article]]~~

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*TGF-β

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|l8=Immune Tolerance

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~~|<big>'''What is the definition of tolerance?'''~~

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|q9=The mechanism of suppression of Treg cells depends on the binding of which receptors?

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~~|| <big>~~

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|a9=Treg CTLA-4 to target cell B7

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*'''''A state of immune unresponsiveness towards antigens'''''

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|l9=Immune Tolerance

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~~||[[Immune Tolerance|Link to Answer Article]]~~

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|q10=What is the transcription repressor unique to Treg cells?

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|-

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|a10=FoxP3

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~~|<big>~~'''What subtype are regulatory T cells?~~'''~~

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|l10=Immune Tolerance

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|~~| <big>~~

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</FlashCard>

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*'''''CD4+~~'''''~~

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|-

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~~|<big>'''~~What part of the body do Treg cells develop?~~'''~~

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|~~| <big>~~

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*'''''Thymus~~'''''~~

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|-

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~~|<big>'''~~What typical inhibitory cytokines do Treg cells secrete?~~'''~~

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|~~| <big>~~

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*~~'''''~~IL-4~~'''''~~

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*~~'''''~~IL-10~~'''''~~

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*~~'''''~~TGF-β~~'''''~~

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|-

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~~|<big>'''~~The mechanism of suppression of Treg cells depends on the binding of which receptors?~~'''~~

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|~~| <big>~~

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*'''''Treg CTLA-4 to target cell B7~~'''''~~

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|~~|[[~~Immune Tolerance|~~Link to Answer Article]]~~

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|-

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~~|<big>'''~~What is the transcription repressor unique to Treg cells?~~'''~~

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||~~~~ <~~big~~>

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*'''''FoxP3'''''

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~~||[[Immune Tolerance|~~<~~span title="Answer article"~~>~~Link to Answer Article~~<~~/span~~>]]

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|}

[[Category:Immunology Flashcards]]

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