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→Complement Fixation Pathways
*iC3b is inactive in the complement cascade but is a major target for phagocytes
*iC3b is inactive in the complement cascade but is a major target for phagocytes
**Phagocytes have large numbers of iC3b receptors (complement receptors) which give opsonisation when engaged. </p>
**Phagocytes have large numbers of iC3b receptors (complement receptors) which give opsonisation when engaged. </p>
[[Image:Complement Mannose Binding Lectin Pathway.png|thumb|right|250px|'''Mannose Binding Lectin pathway in detail''']]
<p>The main effects of alternative complement activation are therefore:
<p>The main effects of alternative complement activation are therefore:
#To coat bacteria with iC3b
#To coat bacteria with iC3b
#*Induce the production of the cytokines (IL-1β and TNFα) responsible for acute inflammation</p>
#*Induce the production of the cytokines (IL-1β and TNFα) responsible for acute inflammation</p>
===MB-Lectin Pathway===
===Mannose Binding-Lectin Pathway===
<p>Lectins are proteins that bind carbohydrates e.g. collectins. They bind carbohydrates that have a terminal mannose residue and are called mannose-binding lectins.
<p>Lectins are proteins that bind carbohydrates e.g. collectins. They bind carbohydrates that have a terminal mannose residue and are called mannose-binding lectins.
*Secreted by the liver into plasma.
*Secreted by the liver into plasma.