Changes

[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p>^{© Nottingham Uni}]]

[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p>^{© Nottingham Uni}]]

* If pathogens breach the barriers formed by the skin and mucus membranes, they must be detected and destroyed by cellular and humoral means  

Pathogens can invade the body if a breach occurs in the barriers formed by the skin and mucus membranes, for example a wound, they must be detected and destroyed by cellular and humoral means.<br />

* The cells involved with innate protection are:

** Blood granulocytes, or Polymorphonuclear Cells

The cells involved in the cellular response to a wound are:

*** Notable for their multi-lobed nuclei

* Tissue mast cells and '''[[Macrtophages|macrophages]]''' that initially phagocytose and detect bacteria<br />

*** '''Neutrophils''': phagocytose bacteria

*** '''Eosinophils''': kill parasites by the release of granules

* The Blood granulocytes, or Polymorphonuclear (multi-lobed nuclei) Cells

*** '''Basophils/ mast cells''': kill parasites by the release of granules

** The '''[[Neutrophils|Neutrophils]]''' are the most abundant as they are the primary cells that phagocytose bacteria, and the larger fungi

** Blood '''[[Monocytes|monocytes]]''': phagocytose bacteria

** The '''[[Eosinophils|Eosinophils]]''' and '''[[Basophils|Basophils/ mast cells]]''' are only needed in rare circumstances as they are for killing parasites by the release of granules (exocytosis).

*Effectively, innate cellular response seeks to hold off the infection until the [[Adaptive Immune System|adaptive response]] can back it up with a more specific attack

* Blood '''[[Monocytes|monocytes]]''': phagocytose bacteria

The main role of the innate cellular response is to delay systemic infection until the [[Adaptive Immune System|adaptive response]] can back it up with a more specific attack

==[[Macrophages|Macrophages]]==

==[[Macrophages|Macrophages]]==