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To then either kill the pathogens or digest the dead cells, '''lysosomes''', which contain a large range of enzymes, fuse with the phagosome to form the '''phagolysosome'''. One example of a process that occurs in these vesicles is oxygen-dependent degradation which utilizes oxygen (O<sub>2</sub><sup>-</sup>) and chlorine (Cl*) free-radicals, hydrogen peroxide (OH), and nitric oxide (NO) to degrade the contents within the phagolysosome. The essential enzyme within this process is NADPH oxidase. In humans, the lethal genetic disease chronic granulomatous disease (CGD) is caused by the lack of NADPH oxidase in the phagocytes, with sufferers rarely living past their mid-twenties (with the help of antibiotics) usually succumbing to lung infection.
To then either kill the pathogens or digest the dead cells, '''lysosomes''', which contain a large range of enzymes, fuse with the phagosome to form the '''phagolysosome'''. One example of a process that occurs in these vesicles is oxygen-dependent degradation which utilizes oxygen (O<sub>2</sub><sup>-</sup>) and chlorine (Cl*) free-radicals, hydrogen peroxide (OH), and nitric oxide (NO) to degrade the contents within the phagolysosome (OH + Cl* = HOCl (otherwise known as bleach!)). The essential enzyme within this process is NADPH oxidase. In humans, the lethal genetic disease chronic granulomatous disease (CGD) is caused by the lack of NADPH oxidase in the phagocytes, with sufferers rarely living past their mid-twenties (with the help of antibiotics) usually succumbing to lung infection.
* Glycosidases: Digest carbohydrates
* Glycosidases: Digest carbohydrates
* Lipases: Digest lipids
* Lipases: Digest lipids
* Proteases: Digest protein
* Proteases: Digest protein (an important example is cathepsin)
The waste products of phagocytosis are then either exocytosed or further degraded by the phagocyte.
The waste products of phagocytosis are then either exocytosed or further degraded by the phagocyte.