Cross-linking two Fc regions of IgM and IgG by complement component C1q begins the [[Classical Complement Pathway| classical complement pathway]]. As IgM has '''five''' Fc regions it is a much better activator of complement than IgG (as IgG only has '''one''' Fc region).
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Cross-linking two Fc regions of IgM and IgG by complement component C1q begins the [[Complement| classical complement pathway]]. As IgM has '''five''' Fc regions it is a much better activator of complement than IgG (as IgG only has '''one''' Fc region).