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→Cytotoxic T-Cells
==Cytotoxic T-Cells==
==Cytotoxic T-Cells==
Cytotoxic T cells kill virus infected cells where the organisms are contained in the cell cytoplasm. Viruses are obligate intracellular pathogens that use the host cell machinery for pathogen protein synthesis; viral peptides associate with MHC class I and are expressed on the cell surface. [[T_cells#Cytotoxic_CD8.2B|CD8+ cytotoxic T lymphocytes (CTL)]] recognise the antigen-MHC complex. Cytotoxic T-cells secrete a pattern of cytokines similar to that of TH<sub>1</sub> cells:
Cytotoxic T cells kill virus infected cells where the organisms are contained in the cell cytoplasm. Viruses are obligate intracellular pathogens that use the host cell machinery for pathogen protein synthesis; viral peptides associate with MHC class I and are expressed on the cell surface. [[T_cells#Cytotoxic_CD8.2B|CD8<sup>+</sup> cytotoxic T lymphocytes (CTL)]] recognise the antigen-MHC complex. Cytotoxic T-cells secrete a pattern of cytokines similar to that of TH<sub>1</sub> cells:
*IFNγ but not IL-2. The IFNγ shifts the balance of the immune response in favour of TH<sub>1</sub> cells and there is therefore an increased level of T-cell proliferation. The initiation of the immune response via CTL leads to the selective proliferation of CTL which enhances the main mechanism of killing virally-infected cells.
*IFNγ but not IL-2. The IFNγ shifts the balance of the immune response in favour of TH<sub>1</sub> cells and there is therefore an increased level of T-cell proliferation. The initiation of the immune response via CTL leads to the selective proliferation of CTL which enhances the main mechanism of killing virally-infected cells.