<p>TH<sub>0</sub> populations are CD4<sup>+</sup> cells that have yet to differentiate into TH<sub>1</sub>, TH<sub>2</sub> or TH<sub>17</sub> cells and they secrete IL-2, IL-4, IL-5, IFN-γ. In the presence of IL-4 they develop into TH<sub>2</sub> cells while in the presence of IL-2 they develop into TH<sub>1</sub> cells. In the abscence of IL-2 TH<sub>1</sub> cells will change into TH<sub>2</sub> cells. TH<sub>17</sub> cells develop in the presence of TGF-β and IL-6 and can further develop into TH<sub>1</sub> cells depending on various conditions. </p> | <p>TH<sub>0</sub> populations are CD4<sup>+</sup> cells that have yet to differentiate into TH<sub>1</sub>, TH<sub>2</sub> or TH<sub>17</sub> cells and they secrete IL-2, IL-4, IL-5, IFN-γ. In the presence of IL-4 they develop into TH<sub>2</sub> cells while in the presence of IL-2 they develop into TH<sub>1</sub> cells. In the abscence of IL-2 TH<sub>1</sub> cells will change into TH<sub>2</sub> cells. TH<sub>17</sub> cells develop in the presence of TGF-β and IL-6 and can further develop into TH<sub>1</sub> cells depending on various conditions. </p> |