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→Introduction
==Introduction==
==Introduction==
<p>Mature [[B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either '''plasma''' or '''memory''' cells. </p>
<p>Mature [[B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either '''plasma''' or '''memory''' cells. </p>
<p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of Il-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however small number become memory cells.</p>
<p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of IL-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however a small number will become memory cells.</p>
Follicular dendritic cells present in the germinal centers of peripheral lymphoid organs can absorb intact antigen onto their surface to present to B cells to stimulate differentiation.
Follicular dendritic cells present in the germinal centers of peripheral lymphoid organs can absorb intact antigen onto their surface to present to B cells to stimulate differentiation.