Both T<sub>H</sub>1 and T<sub>H</sub>2 cells produce IL-3 and granulocyte-macrophage colony stimulating factor ([[Leukopoiesis|GM-CSF]]). These act to activate and induce proliferation of [[Neutrophils|neutrophils]] and [[Macrophages|macrophages]]. [[Neutrophils|Neutrophils]] are the major phagocytic cells in the blood and the principal cells in acute inflammatory lesions whose function is chiefly the body's defence against extracellular bacteria. One of the major biological functions therefore of the activation of either T<sub>H</sub> subset is '''cytokine-controlled reactive [[Haematopoiesis - Overview|haematopoiesis]]'''. | Both T<sub>H</sub>1 and T<sub>H</sub>2 cells produce IL-3 and granulocyte-macrophage colony stimulating factor ([[Leukopoiesis|GM-CSF]]). These act to activate and induce proliferation of [[Neutrophils|neutrophils]] and [[Macrophages|macrophages]]. [[Neutrophils|Neutrophils]] are the major phagocytic cells in the blood and the principal cells in acute inflammatory lesions whose function is chiefly the body's defence against extracellular bacteria. One of the major biological functions therefore of the activation of either T<sub>H</sub> subset is '''cytokine-controlled reactive [[Haematopoiesis - Overview|haematopoiesis]]'''. |