As previously explained, parturition is dependent on a rise in foetal cortisol. However, in this case, the rise in foetal cortisol leads to a decrease in '''maternal''' progesterone. Foetal cortisol causes upregulation of the enzymes, '''17α hydroxylase, C17-C20-lyase and aromatase''' in order to increase the oestrogen:progesterone ratio. | As previously explained, parturition is dependent on a rise in foetal cortisol. However, in this case, the rise in foetal cortisol leads to a decrease in '''maternal''' progesterone. Foetal cortisol causes upregulation of the enzymes, '''17α hydroxylase, C17-C20-lyase and aromatase''' in order to increase the oestrogen:progesterone ratio. |