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Emetics and Anti-Emetic Drugs (view source)
Revision as of 12:15, 23 July 2012
, 12:15, 23 July 2012→Dopamine 2 (D2) Receptor Antagonists
===Dopamine 2 (D<sub>2</sub>) Receptor Agonists===
===Dopamine 2 (D<sub>2</sub>) Receptor Antagonists===
One class of drugs the '''phenothiazines''' inhibit unselectively M, H<sub>1</sub>, and alpha receptors as well as D<sub>2</sub> receptors. This means that they have additional effects, such as sedation and hypotension. These drugs are further discussed on the [[anaesthesia]] pages, but examples are '''acepromazine, chlorpromazine''' and '''proclorperazide'''.
One class of drugs the '''phenothiazines''' inhibit unselectively M, H<sub>1</sub>, and alpha receptors as well as D<sub>2</sub> receptors. This means that they have additional effects, such as sedation and hypotension. These drugs are further discussed on the [[anaesthesia]] pages, but examples are '''acepromazine, chlorpromazine''' and '''proclorperazide'''.
'''Metoclopramide''' isn't a phenothiazine but also acts on the D<sub>2</sub> receptors, it also though works on serotonin receptor. It inhibits some serotonin receptors (5-HT<sub>3</sub>) and activates others (5-HT<sub>4</sub>). This results in reducing inputs into the vomiting center and also increases gastric emptying and gastrointestinal tract motility.
'''Metoclopramide''' isn't a phenothiazine but also acts on the D<sub>2</sub> receptors, it also though works on serotonin receptor. It inhibits some serotonin receptors (5-HT<sub>3</sub>) and activates others (5-HT<sub>4</sub>). This results in reducing inputs into the vomiting center and also increases gastric emptying and gastrointestinal tract motility.
===5-HT<sub>3</sub> Receptor Antagonists===
===5-HT<sub>3</sub> Receptor Antagonists===