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*Important zoonoses worldwide
*Important zoonoses worldwide
*Cause chronic granulomatous diseases
*Cause chronic granulomatous diseases
*6 species
*Target reproductive organs of certain species
*Infected animals act as reservoir of infection
*Organisms can remain viable in moist environment for months
*Cause undulant fever in humans
*Small, non-moltile, Gram negative coccobacilli
*Small, non-moltile, Gram negative coccobacilli
*Facultatice intracellular pathogens
*Facultatice intracellular pathogens
*Modified Ziehl-Neelsen positive - clusters of red coccobacilli on smears
*Aerobic and capnophilic
*Catalase positive; oxidase and urease positive except for ''Brucella ovis''
*Some species require enriched media for growth
*Non-haemolytic
*Smooth colonies of ''B. abortus, B. melitensis'' and ''B. suis'' are small, glistening, blue and translucent after incubation for 3-5 days, and become opaque with age
*Rough colonies of ''B. ovis'' and ''B. canis'' are dull, yellow, opaque and friable
*Slide agglutination with speicific antisera detect important antigens
*''B. abortus'' lysed by specific bacterophages
*Oxidative metaboloic rates can differentiate species
===Pathogenesis and pathogenicity===
===Pathogenesis and pathogenicity===