Changes

===Epidermis===

===Epidermis===

The epidermis is a stratified squamous epithelium and is composed of 4 cell layers anchored to a basal lamina of connective tissue.   

The epidermis is a stratified squamous epithelium and is composed of 4 cell layers anchored to a basal lamina of connective tissue.  Keratinocytes migrate through the epidermis from the basal layer.  This migration begins in the stratum basale, then moves up through the stratum spinosum, stratum granulosum and the stratum corneum.

*'''Stratum Corneum'''

*'''Stratum basale'''

The outer layer, ''stratum corneum'', consists of cells filled with keratin filaments and proteins that form a cell envelope resistant to solvents and enzymes; there is also a permeability barrier to water and ions.  The cells of the stratum corneum are embedded in a lipid-rich matrix which helps to hold the cells together, while the desmosomes that were present in lower layers have disappeared.  For the stratum corneum to maintain a constant thickness, there is a constant turnover of exfoliated corneocytes, being replaced by new corneocytes.  Enzymes in the lamellar bodies from the '''stratum granulosum''' help to break down the intercellular lipid 'glue' that holds the cells in place and there is also some degradation of desmosomes.

The deepest layer of the epidermis is the ''stratum basale''.  It consists of a single layer of columnar epithelium which is adhered to the basal lamina.  Nutrition is supplied from the underlying capillaries of the dermis.  Migration of cells towards the surface begins here.

 

*'''Stratum spinosum'''

Above the stratum basale is the ''stratum spinosum''.  Spinous cells are large polygonal cells with prominent desmosomal intercellular filaments.  When cells move into this layer, they shrink and move apart.  Keratinisation begins in the stratum spinosum and continues in the stratum granulosum.

*'''Stratum Granulosum'''

*'''Stratum Granulosum'''

Deep to the stratum corneum, lies the stratum granulosum.  Granular cells are thin, flattened keratinocytes with variably prominent keratohyaline granules.  At its outer surface, the stratum granulosum secretes oragnelles called '''lamellar bodies''', which are composed of lipid and enzymes which fuse with the plasma membrane and help to form the water concentration gradient that leads to transepidermal water loss.

External to the stratum spinosum, lies the ''stratum granulosum''.  Granular cells are thin, flattened keratinocytes with variably prominent keratohyaline granules.  At its outer surface, the stratum granulosum secretes oragnelles called '''lamellar bodies''', which are composed of lipid and enzymes which fuse with the plasma membrane and help to form the water concentration gradient that leads to transepidermal water loss.

 

The outer layer, ''stratum corneum'', consists of anucleate, thin cells filled with keratin filaments and proteins that form a cell envelope resistant to solvents and enzymes; there is also a permeability barrier to water and ions.  The cells of the stratum corneum are embedded in a lipid-rich matrix which helps to hold the cells together, while the desmosomes that were present in lower layers have disappeared.  For the stratum corneum to maintain a constant thickness, there is a constant turnover of exfoliated corneocytes, being replaced by new corneocytes.  Enzymes in the lamellar bodies from the '''stratum granulosum''' help to break down the intercellular lipid 'glue' that holds the cells in place and there is also some degradation of desmosomes.

===Dermis===

===Dermis===