Changes

===Dermis===

===Dermis===

The epidermis interfaces with the underlying dermis at the '''basement membrane zone (BMZ)'''.  The binding includes anchoring junctions called ''hemidesmosomes'' and ''focal adhesions''.  The former comprise ECM proteins such as '''laminin-5''' and '''type IV collage''' molecules, which form the lamina densa part of the BMZ.  Collagen type VII is important in forming anchoring fibrils between the dermis and the basal lamina.

The epidermis interfaces with the underlying dermis at the '''basement membrane zone (BMZ)'''.  The binding includes anchoring junctions called ''hemidesmosomes'' and ''focal adhesions''.  The former comprise ECM proteins such as '''laminin-5''' and '''type IV collagen''' molecules, which form the lamina densa part of the BMZ.  '''Collagen type VII''' is important in forming anchoring fibrils between the dermis and the basal lamina.

Rete ridges are epidermal projections into the dermis in areas of mechanical loading such as the nasal planum and footpads.

Rete ridges are epidermal projections into the dermis in areas of mechanical loading such as the nasal planum and footpads.

The '''dermis''' consists of dense fibrous tissue composed of collagen type I and III, with some elastin fibres and provides a supporting mattress for the carriage of blood vessels, lymphatic vessels, nerves and sensory receptors, '''hair follicles''', sebaceous and sweat glands, with circulating white cells.

The '''dermis''' consists of dense fibrous tissue composed of '''collagen type I and III''', with some elastin fibres and provides a supporting mattress for the carriage of blood vessels, lymphatic vessels, nerves and sensory receptors, '''hair follicles''', sebaceous and sweat glands, with circulating white cells.

===Glands===

===Glands===