− | In the event of blood pressure dropping, [[Kidney Endocrine Function - Anatomy & Physiology#Renin|renin]] is secreted due to the decreased stretch of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Juxtaglomerular Cells|'''juxtaglomerular cells''']] and an increased sympathetic stimulation, triggered by the decreased activation of arterial baroreceptors. This enzyme cleaves the alpha glycoprotein, '''angiotensinogen''', which is released from the [[Liver - Anatomy & Physiology|liver]]. This produces '''angiotensin 1''', which is further converted by [[Angiotensin Converting Enzyme|'''Angiotensin Converting Enzyme''' (ACE)]] to '''angiotensin II''', mainly in the lungs but to a much lesser extent locally in the kidneys. Angiotensin 2 then works to restore blood pressure by inducing constriction of arterioles, which increases vascular resistance, and constricting veins which reduces vascular volume. In this section, we cover its effects on and through the kidneys. | + | In the event of blood pressure dropping, [[Kidney Endocrine Function - Anatomy & Physiology#Renin|renin]] is secreted due to the decreased stretch of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Juxtaglomerular Cells|'''juxtaglomerular cells''']] and an increased sympathetic stimulation, triggered by the decreased activation of arterial baroreceptors. This enzyme cleaves the alpha glycoprotein, '''angiotensinogen''', which is released from the [[Liver - Anatomy & Physiology|liver]]. This produces '''angiotensin 1''', which is further converted by [[Angiotensin Converting Enzyme|'''Angiotensin Converting Enzyme''' (ACE)]] to '''angiotensin II''', mainly in the lungs but to a much lesser extent locally in the kidneys. Angiotensin II then works to restore blood pressure by inducing constriction of peripheral vessels (arterioles), which increases vascular resistance, and constricting veins which reduces vascular volume. In this section, we cover its effects on and through the kidneys.t |