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Parturition Endocrine Control - Anatomy & Physiology (view source)
Revision as of 11:57, 2 July 2008
, 11:57, 2 July 2008no edit summary
'''''Regulation of Prostaglandins'''''
'''''Regulation of Prostaglandins'''''
The uterus is an important site of prostaglandin synthesis. During pregnancy, the presence of the foetus inhibits the production of prostaglandins in order to prevent luteolysis. At parturition, an increase in prostaglandin synthesis is required.
* Prostaglandins are synthesized from '''Arachadonic Acid''', which is derived from '''Glycerophospholipids''' by the enzyme '''Phospholipase A2''' (PLA2).
** '''Oestrogen''' liberates Phospholipase A2 from lysosomes.
** '''Progesterone''' stabilises lysosomes, so Phospholipase A2 cannot be liberated from lysosomes.
* An increase in '''Oestrogen:Progesterone ratio''' increases prostaglandin production.
* The increase in '''Oestradiol''' (bioactive oestrogen) also increases expression of '''endometrial Oxytocin receptors'''.
'''''Regulation of Oxytocin'''''