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2 bytes added ,  08:11, 26 May 2014
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'''Caution should be taken in if the animal suffers from any of the following pre-existing medical conditions:'''
 
'''Caution should be taken in if the animal suffers from any of the following pre-existing medical conditions:'''
*Heart disease, especially heart block and arrythmias.
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*Heart disease, especially heart block and arrythmias
*Diabetes: increases hyperglycaemia.
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*Diabetes: increases hyperglycaemia
*Glaucoma [closed angle type].
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*Glaucoma [closed angle type]
 
*Impaired liver function [TCAs metabolised by liver]
 
*Impaired liver function [TCAs metabolised by liver]
 
*Hyperthyroidism [enhanced response to TCAs]
 
*Hyperthyroidism [enhanced response to TCAs]
    
'''Care should be taken if used in conjunction with any of the following drugs, which may interact and cause adverse effects:'''
 
'''Care should be taken if used in conjunction with any of the following drugs, which may interact and cause adverse effects:'''
*Morphine: enhanced analgesia and respiratory depression
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*Morphine: enhanced analgesia and respiratory depression.
 
*MAOIs: risk of serotonin syndrome, advise washout period of 2-3 weeks between treatment with these drugs.
 
*MAOIs: risk of serotonin syndrome, advise washout period of 2-3 weeks between treatment with these drugs.
 
*Phenothiazines: increased shared adverse effects [CVS, etc], mutual increase in serum levels due to competition for cytochrome p450. Definite risk of severe adverse affects and toxicity.
 
*Phenothiazines: increased shared adverse effects [CVS, etc], mutual increase in serum levels due to competition for cytochrome p450. Definite risk of severe adverse affects and toxicity.
*SSRIs: Fluoxetine inhibits Cytochrome p450, leading to toxic levels of TCA.
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*SSRIs: Fluoxetine inhibits Cytochrome p450, leading to toxic levels of TCA. Cimetidine also has this effect.
*Cimetidine does the same.
   
*Fibre rich diets reduce availability of TCAs.
 
*Fibre rich diets reduce availability of TCAs.
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*Head pain
 
*Head pain
 
*Agitation
 
*Agitation
*Increased heart rate, body temperature, respiratory rate.
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*Increased heart rate, body temperature, respiratory rate
 
*Muscular rigidity
 
*Muscular rigidity
 
*Convulsions
 
*Convulsions

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