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Behaviour Modifying Drugs - Overview (view source)
Revision as of 18:31, 26 May 2014
, 18:31, 26 May 2014no edit summary
| Monoamine Oxidase Inhibitors || Selegiline || Canine and feline cognitive dysfunction syndrome || GI effects, restlessness or lethargy, anorexia
| Monoamine Oxidase Inhibitors || Selegiline || Canine and feline cognitive dysfunction syndrome || GI effects, restlessness or lethargy, anorexia
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Benzodiazepines are the only class of drug that consistently succeed in all models, but this may be why they have a dangerous disinhibitory effect on aggression. These drugs eliminate avoidant responses to many kinds of aversive events, increasing confidence in a number of exploratory tests. This is why benzodiazepines can cause dangerous levels of disinhibition in aggressive dogs.
Benzodiazepines also inhibit memory formation by affecting NMDA (glutamate) receptors in the hippocampus, which limits their usefulness in behavioural therapy where any kind of learning is required (i.e. most situations!). They are useful for memory blocking if given at sub-sedative doses prior to or during a predicted traumatic event such as a thunderstorm.