Changes

[[Cystitis|Feline idiopathic cystitis]] (FIC) is a complex condition that involves neurological changes in spinal pain fibres and biochemical changes in the bladder wall. The precise aetiology is not fully understood but there appears to be an association between stress and FIC. Bladder permeability in FIC affected cats is increased by stress<ref>Westropp, J.L., Kass, P.H., Buffington, C.A. (2006) Evaluation of the effects of stress in cats with idiopathic cystitis. "Am J Vet Res.". 67(4):731-6.</ref>, and the frequency and severity of signs is associated with stressors such as conflict with another resident cat<ref>Cameron, M.E., Casey, R.A., Bradshaw, J.W., Waran, N.K., Gunn-Moore, D.A. (2004) A study of environmental and behavioural factors that may be associated with feline idiopathic cystitis. "J Small Anim Pract". 45(3):144-7.</ref>. Cats with FIC also appear to show differences in their response to stimuli, being more stress responsive and easily startled by noises<ref>Hague, D.W., Stella, J.L., Buffington, C.A. (2013) Effects of interstitial cystitis on the acoustic startle reflex in cats. "Am J Vet Res". 74(1):144-7.</ref>.Cats with FIC exhibit a characteristic set of sickness behaviours that are the result of inflammatory cytokine activation<ref>Stella, J.L., Lord, L.K., Buffington, C.A.T. (2011) Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis. "J Am Vet Med Assoc". 238:67–73.</ref>.

[[Cystitis|Feline idiopathic cystitis]] (FIC) is a complex condition that involves neurological changes in spinal pain fibres and biochemical changes in the bladder wall. The precise aetiology is not fully understood but there appears to be an association between stress and FIC. Bladder permeability in FIC affected cats is increased by stress<ref>Westropp, J.L., Kass, P.H., Buffington, C.A. (2006) Evaluation of the effects of stress in cats with idiopathic cystitis. "Am J Vet Res.". 67(4):731-6.</ref>, and the frequency and severity of signs is associated with stressors such as conflict with another resident cat<ref>Cameron, M.E., Casey, R.A., Bradshaw, J.W., Waran, N.K., Gunn-Moore, D.A. (2004) A study of environmental and behavioural factors that may be associated with feline idiopathic cystitis. "J Small Anim Pract". 45(3):144-7.</ref>. Cats with FIC also appear to show differences in their response to stimuli, being more stress responsive and easily startled by noises<ref>Hague, D.W., Stella, J.L., Buffington, C.A. (2013) Effects of interstitial cystitis on the acoustic startle reflex in cats. "Am J Vet Res". 74(1):144-7.</ref>.Cats with FIC exhibit a characteristic set of sickness behaviours that are the result of inflammatory cytokine activation<ref>Stella, J.L., Lord, L.K., Buffington, C.A.T. (2011) Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis. "J Am Vet Med Assoc". 238:67–73.</ref>.

This indicates a strong connection between aspects of temperament, environmental stressors and FIC, which has led to the adopt of a multimodal strategy for the treatment of the disease<ref>Buffington, C.A.T., Westropp, J.L., Chew, D.J., (2008). Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis. "J Feline Med Surg". 8:261–268.</ref>.

This indicates a strong connection between aspects of temperament, environmental stressors and FIC, which has led to the adoption of a multimodal strategy for the treatment of the disease<ref>Buffington, C.A.T., Westropp, J.L., Chew, D.J., (2008). Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis. "J Feline Med Surg". 8:261–268.</ref>.

FIC should therefore be considered an important underlying factor in inappropriate elimination in cats.

FIC should therefore be considered an important underlying factor in inappropriate elimination in cats.