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Selective Serotonin Reuptake Inhibitors (Clomipramine, Fluoxetine) (view source)
Revision as of 13:09, 12 September 2014
, 13:09, 12 September 2014→Adverse EffectsWiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.
===Drug withdrawal===
===Drug withdrawal===
In humans, sudden withdrawal of SRI/SSRI/TCA drugs is associated with dysphoria, agitation, increased anxiety, relapse of psychiatric symptoms and, in some cases discontinuation syndrome<ref>Haddad, P.M., Anderson, I.A. (2007) Recognising and managing antidepressant discontinuation symptoms. Advances in Psychiatric Treatment. 13, 447-457</ref>. It is recommended that, unless otherwise indicated by drug monographs, withdrawal should be gradual. Typically a period of 1 week per month of treatment is allowed for withdrawal. This is divided into three periods of equal length with three dose decreases to 75% of original dose, followed by 50% of original dose and finally 25% of original dose.
In humans, sudden withdrawal of SRI/SSRI/TCA drugs is associated with dysphoria, agitation, increased anxiety, relapse of psychiatric symptoms and, in some cases discontinuation syndrome<ref>Haddad, P.M., Anderson, I.A. (2007) Recognising and managing antidepressant discontinuation symptoms. Advances in Psychiatric Treatment. 13, 447-457</ref>. It is recommended that, unless otherwise indicated by drug monographs, withdrawal should be gradual. Typically a period of 1 week per month of treatment is allowed for withdrawal. This is divided into three periods of equal length with three dose decreases to 75% of original dose, followed by 50% of original dose and finally 25% of original dose.
===Adverse Effects<ref>Fluoxetine hydrochloride [https://www.elancocentral.com/Reconcile_Vet_label.pdf data sheet]</ref>===
*Decreased appetite
*Depression/lethargy
*Shaking/shivering/tremor
*Vomiting and diarrhoea
*Restlessness and anxiety
*Seizures
*Aggression
*Mydriasis
*Vocalisation
*Weight loss
*Panting
*Confusion
*Incoordination
*Hypersalivation
==Clomipramine==
==Clomipramine==