Changes

* Diffuses across the cell membrane - lipophillic (essentially steroidal)

* Diffuses across the cell membrane - lipophillic (essentially steroidal)

* Of the principal cells of [[Distal Tubule - Anatomy & Physiology| distal tubule]]

* Of the principal cells of [[Distal Tubule - Anatomy & Physiology| distal tubule]] and [[Collecting Duct - Anatomy & Physiology| Collecting Duct]]

* Binds to cytoplasmic receptors

* Binds to cytoplasmic receptors

* Works by altering gene transcription and increases synthesis of proteins

* Works by altering gene transcription and increases synthesis of proteins