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Pancreas - Anatomy & Physiology (view source)
Revision as of 10:13, 18 July 2008
, 10:13, 18 July 2008→Insulin
**Depolarisation causes calcium signalling, which stimulates insulin to be released.
**Depolarisation causes calcium signalling, which stimulates insulin to be released.
*Pre-formed granules of insulin are release initially, but this supply soon diminishes. This produces a decrease in plasma insulin levels. Insulin levels are restored as de novo insulin is synthesised and secreted.
*Pre-formed granules of insulin are release initially, but this supply soon diminishes. This produces a decrease in plasma insulin levels. Insulin levels are restored as de novo insulin is synthesised and secreted.
*Insulin exerts it's anabolic effect on adipocytes and skeletal muscle.
*Insulin exerts it's anabolic effect on the liver, adipocytes and skeletal muscle.
**It binds to receptors on the cell membrane, which triggers an intracellular signalling cascade.
**It binds to receptors on the cell membrane, which triggers an intracellular signalling cascade.
**This causes preformed granules containing GLUT 4 receptors to be transported and expressed at the cell membrane.
**This causes preformed granules containing GLUT 4 receptors to be transported and expressed at the cell membrane.
**Cells can now take up glucose from the blood and store it as glycogen or fat.
**Cells can now take up glucose from the blood and store it as glycogen or fat.
*Increased glucose levels inside the cell increases the rate of glyogenesis and an increase in the rate of production of triacylglycerides.
*There is an increase in basal metabolic rate in other tissues.
*Insulin regulates the
==Vasculature==
==Vasculature==