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→Biomechanics of Bone
*Cells use strain as a stimulus to adjust mass and architecture according to load
*Cells use strain as a stimulus to adjust mass and architecture according to load
*Resorption and osteogenesis happen concurrently to maintain bone integrity
*Resorption and osteogenesis happen concurrently to maintain bone integrity
**Mediated by two [[Parathyroid Pathology#Hormonal Control|hormones]]:
***'''Parathyroid hormone (PTH)'''
****Produced by <u>chief cells in the parathyroid glands</u> in response to <u>decreased</u> serum calcium
****In response, osteoclasts increase in number and resorb mineralised matrix - increase Ca in blood
***'''Calcitonin'''
****Produced by <u>C-cells in the thyroid glands</u> in response to <u>increased</u> serum calcium
****Inhibits osteoclasts
*In neonates:
*In neonates: