Changes

<p> High endothelial venules (HEV)are composed of cuboidal/columnar epithelium and are the major route for lymphocytes to enter the node. HEV contain a large number of aquaporin-1 channels allowing for a large uptake of water which in turn drives lymph flow through the cortex, this fluid is returned direct to the bloodstream. The venules are the source of most of the nodes T and B cells and express selectins (receptors for lymphocytes primed with antigens).</p>

<p> High endothelial venules (HEV)are composed of cuboidal/columnar epithelium and are the major route for lymphocytes to enter the node. HEV contain a large number of aquaporin-1 channels allowing for a large uptake of water which in turn drives lymph flow through the cortex, this fluid is returned direct to the bloodstream. The venules are the source of most of the nodes T and B cells and express selectins (receptors for lymphocytes primed with antigens).</p>

===Pig Lymph Node===

===Pig Lymph Node===

<p> The structure of the pig lymph node is inverted compared with that of most mammals.

<p> The structure of the pig lymph node is inverted compared with that of most mammals.

* Most follicles are found deep in the paracortex

* Most follicles are found deep in the paracortex

** Connect with para-trabecular sinuses and exit from efferent lymphatics on the node surface.

** Connect with para-trabecular sinuses and exit from efferent lymphatics on the node surface.

* Blood vessels enter and leave at the hilus</p>

* Blood vessels enter and leave at the hilus</p>

===Histology===

===Histology===

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